Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population.

نویسندگان

  • Renata Almeida de Så
  • Aline Dos Santos Moreira
  • Pedro Hernan Cabello
  • Antonio Augusto Ornellas
  • Eduardo Butinhão Costa
  • Cintia da Silva Matos
  • Gilda Alves
  • Ana Hatagima
چکیده

OBJECTIVE To evaluate the influence of polymorphisms in GSTA1, GSTM1, GSTT1, and GSTP1 in the risk of developing Prostate Cancer (PCa) in a population of Rio de Janeiro and compare the distribution of allele and genotype frequencies of the polymorphisms analyzed in the present study population with other regions in the country and different ethnic groups. MATERIALS AND METHODS We analyzed a sample of the Brazilian population, comprising 196 patients with PCa treated by the urology services of the Brazilian National Cancer Institute (INCA) and Mario Kroeff Hospital (HMK), and 208 male blood donors from the Clementino Fraga Filho Hospital, Federal University of Rio de Janeiro (UFRJ). The polymorphisms were determined in DNA, extracted from peripheral blood leucocytes using the Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP). RESULTS Our results showed that the distribution of polymorphisms can vary significantly according to the Brazilian region and ethnic groups. The distribution of allele and genotype frequencies of the polymorphism GSTA1 was statistically different between cases and controls. Genotypes (A / B + B / B) were associated with protection (OR = 0.61, 95% CI = 0.40-0.92) for PCa in comparison to genotype A / A. CONCLUSION The distribution of genotype frequencies of the polymorphism GSTA1 was statistically different between the case and control groups (p = 0.023), and the presence of genotypes A / B and B / B suggests a protective role against the risk of PCa compared to genotype A / A. This is the first study that reports the genotypic frequency of this polymorphism and its association with PCa in a Brazilian population sample.

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AH EA D OF PR IN T Human glutathione S - transferase polymorphisms associated with prostate cancer in the Brazilian population

ARTICLE INFO ______________________________________________________________ ______________________ Objective: To evaluate the influence of polymorphisms in GSTA1, GSTM1, GSTT1, and GSTP1 in the risk of developing Prostate Cancer (PCa) in a population of Rio de Janeiro and compare the distribution of allele and genotype frequencies of the polymorphisms analyzed in the present study population wi...

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عنوان ژورنال:
  • International braz j urol : official journal of the Brazilian Society of Urology

دوره 40 4  شماره 

صفحات  -

تاریخ انتشار 2014